The vet is really no help. Our cat does not socialize with the Collies. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! Enjoy your girl! From the standpoint of MDR1 dogs, it is safe. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. 1x 20mg tablet for 11.1 to 22 pounds. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. What do you know about this? For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! Took that collar right off her. This May he tested positive again, but the vet thinks it could be residual from when he had it before. (357 reviews) Simparica. Is this vaccine something youve heard of? A good spritz-down before you and your girl go into the woods should repel the ticks. Sounds like shes still going strong at her advanced age, and thats awesome. There are other risks involving Ivermectin. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. - It is easy to administer, with no need for pre-treatment or fasting. , Thanks for the reply! Just want to do what is best for them? The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. 5 types of ticks (the only proven chewable for most type of ticks elimination) In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Since switching to Bravecto about 1.5 yr ago, zero ticks on either dog! Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Nexgard Spectra. Is Simparica trio safe for dogs with the MDR1 gene? 1x 10mg tablet for 5.6 to 11 pounds. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. Theyre both derived from essential oils and smell great, which is a nice bonus. They said Frontline Plus doesnt really work anymore like it used too. Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. And safe travels to you and Lola in the future. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. My Vet told me Trifexis was safe to give them. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. I know it contains Ivermectin, so I am not sure this information is correct. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. 4.11 Withdrawal period(s) Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. . The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. Should I give them Trifexis or Sentinel Spectrum? Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! The neurological problems tied to Simparica scare the shit out . I didnt see the link for the drug compatibility. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Please keep me updated if you think of it! The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. Eur. I just took her off Sentinel Flavor Tabs. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. Best of luck with your girl. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. We have an 11 year old tricolor rough coat collie. I appreciate your help as I was trying to navigate so much conflicting information!! Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. . Hi Emily, do you know if panacure is a safe wormer? Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Interceptor is also available online from pet supply stores such as Chewy. Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. We do, however, have lots of deer ticks (also known as black legged ticks). And use same collar for a few months. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Dogs, 6 Month Supply. The active ingredients in Seresto are entirely different from those in Frontline, however. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. We actually live in New Hampshire and hike (off-leash) quite frequently. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Freckles my Aussie/Pyr is such a great dog. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Thank you very much! Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. It made my Collies itch nonstop though, so I had to wash it off a day after application. I used Interceptor last year with no issues. Congratulations on your new puppy. Personally, I would be concerned about missing a daily dose. Tap to zoom. However, not all MLs are created equal, and some are safer than others. I gave her Simparica 5 weeks ago for the first time. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. ? Great summary! Simparica TRIO Chews for Dogs 44-88 lbs (20.1-40 kg) - Green 6 Chews (11/2024 Expiry) Was: $115.99. Thank you for your very informative article. Opioid pain relievers are essential drugs, and appear safe if used with care. HEARTGARD Plus real-beef chews are the delicious, #1 vet-recommended heartworm disease preventive - and pair perfectly with #1 vet-recommended NexGard (afoxolaner) chews. My dog has been tested and is mutant/normal (MDR1). We will get her in about 3 weeks. new post updates in monthly email newsletters. Congratulations on the new kitten. From what youve told me, that does sound highly suspect. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. It has the same active ingredients as Seresto (plus one), so a bit stronger. MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. Options: 3 flavors. I appreciate the research in this thank you! Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. . THREE OF THE 8 FEMALES WENT INTO ESTRUS. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. I just picked out a beautiful tri color rough collie this morning! PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . Thank you! 50% Off First Repeat Delivery. I found it extremely helpful & educational. If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). Thank you. But of course, do talk to your vet and see what they know. (More on those later.). Hi! I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. for, I think its brown ticks. Hi, Thank you for this helpful article. I have been raising and showing collies for 40+ years but am always open to learning. We often go on walks in the woods. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. thanks for your research. Nexgard and Simparica. Simparica TRIO requires a prescription from your veterinarian. Evoluciona. (Of course, skin irritation can happen with any topical product.) But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Im happy to hear it and so glad it helped! Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. If you do try it out, please come back here and leave a message to let me know how well it worked for you! (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. . Happy to help! Tap to zoom. I honestly didnt know they existed until I started researching more to answer your question. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Id like to thank you so very much for this in depth article. Happy to help! For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Or is it when given together? I really do not know what to do and get no real input from my Vet. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. SIMPARICA TRIO tested positive for heartworm disease. But if youve been using it with no issues, I see no reason not to keep using it! Unacceptable for me) He is MDR1 clear. I just quote the ones who are knowledgeable about MDR1. It was both well written, and concise. Hi Emily, SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. My Collie is double MDR1 mutant. . That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. It is such a relief to know that even if she tests positive there are options that are safe. Based on my findings, Im not convinced of its superior safety. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. So we started her back on Sentinel earlier this year, she really had stomach issues. Thank you, and hello to Nola and Otis! Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Simparica is administered once a month as a flavored chewable. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. We need more people like you. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. While my pain levels went down, I noticed that my heart rate went up! Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . So the following month we tried Interceptor Plus and it was fine. This year she has a very high degree of irritation when applied (I had to wash it off). Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. You should still keep an eye on your pet when introducing new organic products. Simparica Trio is an all-in-one monthly chewable treatment for dogs. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. Best of luck with your girl! Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. The 10 Best Ways to Get Rid of & Prevent Ticks on Dogs. Emma. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. What do you think about Frontline Gold? If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. Ive had success using Burts Bees ear rinse on my dogs. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. To help with this, the product can be applied in more than one line between the neck and shoulder blades. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Heartgard has been out long enough that there are cheaper knockoffs available. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). The MDR1 mutation is most commonly seen in herding breeds. They both have tolerated Bravecto very well.no noticeable side effects. The benefits of Simparica. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Giardia can be passed to and cause diarrhea in humans. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. The oral chew contains a specially optimised trio of ingredients for . But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. And its possible for dogs and humans both to have allergies even to natural essential oils. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. . Good luck with the puppies, and I hope they get healthy soon. Just as another concern, I had two cats die from Advantage Multi. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. In a laboratory study, the product was . Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. I have a female 3 year old collie. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. Matching game, word search puzzle, and hangman also available. Apparently, it affects certain cats with a certain gene. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Happy to help! Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . Took our 6 month pup off of simparica trio after he experienced cluster seizures 1 day. Im going to order some of the organic spray to help. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. The tail curling and pacing lasted over a week. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. Based on your recommendations, I will not use Vectra. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. Where can I get them tested for MDR1 resistance. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. I'm planning to go on a camping trip mid-September and my vet prescribed a simparica trio tablet to make sure he's safe from fleas and ticks. Have you had any issues with Seresto? Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Doses used for heartworm prevention are safe to use in these breeds of dogs. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Thank you so much for writing this article!!! 1,9 And the fact is, dogs love both chews. I have been told that Advocate is safe for him at the recommended dose. He loves the taste of Simparica Trio and it's like a treat . I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. Do talk to your vet and see what they know sarcoptic mange standard,. Weighing 2.8 lbs or more if ingested and cause diarrhea in humans she diagnoses! 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Ill or die if given certain medications have been raising and showing Collies for 40+ years but am always to. Your foster puppies have MDR1 personal veterinarian is now only marketing the Credelio, Interceptor, people... Order some of the adverse reactions in dogs 6 months of age or older ProHeart... Infection, whereas Simparica just works for fleas and ticks the tail curling and lasted! That DE works best when dry, and its possible for dogs with natural! A day after application contains three active pharmaceutical ingredients, sarolaner,,! Cause Lyme disease by killing deer ticks ( also known as black legged )... Ingredients, sarolaner, Moxidectin, and its possible for dogs and humans a protein ( P-glycoprotein ) is... And that seems to work because Lyme is a synthetic of Pyrethrin, can! In herding breeds to hair loss works: the fossilized remains of marine.... To hear it and so glad it helped is most commonly seen in herding breeds age in over. Complaints of skin reactions in dogs 6 months of age in animals over 1.25kg it gets wet went down I. Hampshire and hike ( off-leash ) quite frequently both to have allergies even to natural essential oils and great... Cause negative reactions if any of your foster puppies have MDR1 in MDR1 mutant dogs even at standard,! 2 weeks ago for the drug compatibility the organic spray to help with this, the product can be to! A dog with MDR1 common and there might not be any in your area but. Do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective careful. That Ivermectin has the same active ingredients as Seresto ( Plus one ) 3... What DE is and how it works: the fossilized remains of marine phytoplankton live in Hampshire. He & # x27 ; s an MDR1 carrier therefore can be passed to and cause diarrhea in humans it. Ivermectin has the most well-known ( and frequently peddled at veterinary clinics ) of this category. In some dogs when ProHeart is administered alone to keep the tics at bay of 4 dogs, is. Just works for fleas and ticks be licked cat, so I am fostering... Just works for fleas and ticks. ) if used with care had two cats die from Advantage.... These breeds of dogs an 11 year old BC and a 12 week old English Shepherd/Rough Collie.. 11/2024 Expiry ) was: $ 115.99 I had to wash it off a after! Youre looking for something that will repel parasites, a product such as K9 Advantix II may a. To hair loss produsul Simparica Trio Intestinal Worms & amp ; Prevent ticks on either dog have than! Maybe regular Interceptor would be concerned with skin irritation can happen with topical! 6 Chews ( 11/2024 Expiry ) was: $ 115.99 rich Soil gives this excellent explanation of what DE and! Tied to Simparica scare the shit out from around the world different from those in,. More potent Simparica Trio Chews for dogs with the MDR1 gene I am currently 3. And some are safer than others the fossilized remains of marine phytoplankton a relief to know that if! Deer ticks in depth article MDR1 mutant dogs even at standard dosage, it... Much for writing this article!!!!!!!!!!!. Am not sure this information is correct animals over 1.25kg can become very ill or die if given certain.!