This can cause Zetia to be less effective. Its not known if Zetia is safe to take during pregnancy. Yes, there are a few. The following lists contain some of the key side effects that may occur while taking Zetia. We talked to experts about, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Zetia side effects. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Get answers to some frequently asked questions about Zetias side effects. For most people, CoQ10 isnt a harmful or dangerous supplement. It isnt safe to eat grapefruit or drink grapefruit juice while using statins. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. Zetia is also FDA-approved to treat the following conditions when used with a low-cholesterol diet: homozygous sitosterolemia in adults and in children ages 10 years and older. Examples of bile acid sequestrants include: Zetia inhibits the intestinal absorption of cholesterol and phytosterols, resulting in a decrease in the transport of intestinal cholesterol to the liver. Zetia can cause certain side effects, some of which are more common than others. Total cholesterol is the overall amount of cholesterol found in your blood. Zetia contains the active drug ezetimibe. The phase IV clinical study analyzes which people take Zetia and have Constipation. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. Zetia is meant to be used as a long-term treatment. However, some people have reported experiencing memory loss when taking statin drugs. Both Zetia and Lipitor come as tablets that are swallowed. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. Zetia is also available in a generic form called ezetimibe. If you and your doctor determine that Zetia is safe and effective for you, youll likely take it long term. Zetia may be used with statin drugs to treat the following conditions in adults: Statins are another class of medications used to lower cholesterol. diarrhea. At the end of the study, researchers found that: Mixed hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol and fats are cleared from your body. The symptoms develop immediately and include dizziness and an intense headache. Stopping Zetia treatment shouldnt cause any noticeable side effects. Females who could become pregnant should use birth control while taking Zetia with a statin drug. Some people experience mild side effects with Zetia. Recently, POTS has been diagnosed in some people who have had COVID-19. Brand-name medications usually cost more than generics. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. Learn how we can help. Legal news and analysis on health care, hospitals, insurers, medical suppliers. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about the change in her physical appearance. Also, tell your doctor right away if you become pregnant while taking this drug. It can cause mild side effects and, less commonly, serious side effects. Statin drugs arent safe to use during pregnancy. Ways to reduce the symptoms. In these groups, joint pain occurred in: The length of time that adults and children experienced joint pain while taking Zetia in these clinical studies isnt known. Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by lightheadedness or dizziness when standing and a racing heart. But in studies, some people had to stop taking the drug due to feeling dizzy. This lack of blood to the brain and other organs can cause a variety of symptoms, including: Fainting. Most of these side effects may go away within a few days or a couple of weeks. Youll likely take Zetia once a day. (Fenofibrate is a drug used to lower your triglyceride levels.). The insurance company will review the prior authorization request and decide if the drug will be covered. Here we look at how Zetia and Crestor are alike and different. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. If your doctor has prescribed Zetia and youre interested in using ezetimibe instead, talk with your doctor. Using Zetia for high cholesterol. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. However, its important that you dont stop taking Zetia without first talking with your doctor. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! Get medical help right away, if you have any of the symptoms listed above. In clinical studies that lasted 8 weeks, Zetia was compared with a placebo (a treatment with no active drug). Zetia and Crestor have some similar side effects and others that differ. However, you may still experience muscle problems if you use Zetia alone. If your doctor confirms you had a serious allergic reaction to Zetia, they may have you switch to a different treatment. Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition. Zetia is a prescription drug used to treat certain types of high cholesterol. Statins are drugs used to lower cholesterol. However, it isnt known how Zetia may affect these risks. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). Zetia is approved to treat different types of high cholesterol. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. Absorption isnt affected by food. Different interactions can cause different effects. If youve noticed memory problems while taking Zetia, talk with your doctor. Lipitor is available in a generic form called atorvastatin. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. These lists dont include all possible side effects. People with this condition have high levels of plant sterols. This helps prevent others, including children and pets, from taking the drug by accident. The causes of POTS are unknown, but the problem is thought to lie in the communication breakdown between the brain and the cardiovascular system. What are the more common side effects of Zetia? In order to diagnose POTS, your doctor will need to measure your heart rate when you are sitting at rest. If taking your dose at bedtime doesnt help, or if dizziness becomes severe, tell your doctor. Nexlizet (bempedoic acid/ezetimibe) is a prescription tablet used to lower LDL (bad) cholesterol in certain people. Postural Orthostatic Tachycardia Syndrome (POTS) is a blood flow disorder that causes a sudden spike in heartbeat with no change in blood pressure when going from a horizontal or seated to a standing position. The generic is considered to be as safe and effective as the original drug. Zetia and Lipitor are both brand-name drugs. pain in your arms or legs. For more information, see the Precautions section below. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. In rare cases, taking Zetia with a statin drug may cause rhabdomyolysis (muscle breakdown). Diarrhea is a common side effect of Zetia. fainting (passing out) problems with thinking, memory and concentration - this combination of symptoms is often called 'brain fog'. In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). The Food and Drug Administration (FDA) approves prescription drugs such as Zetia to treat certain conditions. See the Mild side effects and Serious side effects sections above for more information. It can develop suddenly or gradually over time. For information on the effectiveness of Zetia, see the Zetia uses section below. (A class of drugs is a group of medications that work in a similar way.) In addition, you may need to watch out for grapefruit. Theyll guide you with suggestions they may have to relieve these side effects. This drug has not been studied in pregnant females.*. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Any time youre considering taking a supplement, its important to discuss this with your doctor or pharmacist. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. Zetia comes as a tablet that you swallow. Zetia contains the active drug ezetimibe. Some people witness mild symptoms, some have a big impact on their lives due . If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. Pots or postural tachycardia syndrome is, also known as postural orthostatic tachycardia syndrome, is a condition that affects the flow of blood in the heart and brain. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. You should also look for supplements from reputable manufacturers. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. Zetia is available in a strength of 10 milligrams (mg). And generics tend to cost less than brand-name drugs. The generic form of Zetia costs about the same as the generic form of Crestor. Dr. John Szawaluk answered. The heartbeat increases with a feeling of the heart fluttering. Tramadol will usually cause a blistering type rash with itching which you do not describe. Before trying something new, its common to look for written reviews about the experiences of others. Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. Taking Zetia with a statin may cause this side effect. Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. 4. POTS is commonly associated with low levels of fluid. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. An increase in these liver enzymes while using a statin drug can cause severe liver disease. It can also interact with certain supplements as well as certain foods. It also isnt known how many adults and children experienced joint pain in clinical studies of Zetia used to treat other conditions. Lying down on the bed, and raising your legs. These tests will look at your cholesterol levels and also your liver enzyme levels. muscle pain while taking ezetimibe with a statin. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Call your doctor right away if you have serious side effects. Zetia is FDA-approved to treat certain types of high cholesterol in adults and in children when used with a low-cholesterol diet. Currently, no medications have been approved by the FDA to treat POTS. If your muscle-related side effects dont go away or become severe, tell your doctor right away. This in turn increases clearance of cholesterol from the blood. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. It's Aimee Esther here! Below are examples of these side effects. Cholesterol is made naturally in your liver. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. Symptoms: This section is currently in development. Zetia is indicated as an adjunct to a low-cholesterol diet for treatment of the following types of hyperlipidemia: For treatment of primary hyperlipidemia, Zetia is indicated to reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and apiloprotein B (ApoB). (Primary hyperlipidemia is also called primary high cholesterol.) The generic is considered to be as safe and effective as the original drug. Liver problems. The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . 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